Citicoline sodium (citicoline) has a broad spectrum of therapeutic index, as a neuroprotectant or cerebroprotectant.Citicoline is useful in the treatment of ischemic stroke, head trauma and neurodegenerative disease. The present study was planned to develop controlled release tablets of citicoline. The effect of various hydrophilic and hydrophobic polymers on controlling release of the drug was studied by using Hydroxypropylmethyl Cellulose, Hydroxypropyl Cellulose, Methacrylic acid copolymers (Eudragit RSPO, Eudragit RLPO). Tablets were prepared by wet granulation method using non aqueous granulation fluid. Tablets were evaluated for physical, drug content and in-vitro release properties. Promising results were obtained with tablets prepared by using Eudragit RSPO in controlling the release of the drug for extended period of time. The drug release followed Zero order, Higuchi square root and Peppas & Korsmeyer kinetics with diffusion mechanism. Stability studies indicated the dosage form is stable for 3 months at accelerated condtions of 40°C± 2°C&75%±5 % RH.
