Alfuzosin Hydrochloride extended release tablets were prepared by wet granulation method by using natural and synthetic polymers Guar gum, Eudragit RLPO and Hypromellose (Methocel K100M). The present study was to develop stable and robust formulation of Alfuzosin Hydrochloride ER tablets 10mg. The formulation containing binary mixer of Hypromellose at 31.0 % and Guar gum at 11.0 % were evaluated for various physicochemical parameters by official procedures showed consistent results. The in-vitro release study of tablets was carried out in 0.01N HCL for 20 hours. A time (hr.) interval 1, 2, 6, 12, and 20 has showed the best formulation releases when compared with the reference product. Both the diffusion and erosion mechanisms were responsible for drug release as shown by the power law. Dissolution data were fitted to zero order, first order, Higuchi's, Peppas & Korsmeyer, Hixson Crowell, Weibull and Baker Lonsdale release kinetics to evaluate kinetic data. The main effect and interaction terms were quantitatively evaluated using mathematical model. Hence the gradual release of Alfuzosin Hydrochloride over a prolonged time period of 20 hr. which indicates the usefulness of the formulation for once daily dosage form. Optimized formulation was found stable during accelerated stability study for 3 months at 40°C± 2°&75%±5 % RH.
