Der Pharmacia Lettre
Abstract
Author(s): Doddayya Hiremath, Prakash S.Goudanavar, Dipak S. Phalak,
Raghavendra Kulkarni and Sarfaraz Md.
This work aims at investigating different types and levels of hydrophilic matrix agents from
synthetic origin, hydroxypropyl methylcellulose K100M, and from natural origin, gum karaya, in
an attempt to formulate extended release matrix tablets of itopride hydrochloride. HPMC and
gum karaya were used alone and in combination to know their efficacy in controlling the release
rate of a highly water soluble drug itopride hydrochloride. Itopride hydrochloride is the
prokinetic agent which improves GI motility by a dual mode of action, dopamine D2 receptor
blockade and acetyl cholinesterase inhibitory action. The tablets, prepared by direct
compression, were subjected to physical characterization. Physicochemical interactions between
the drugs with excipients were determined by using FTIR and DSC which revealed that there is
no interaction between drug with excipients. All the precompression and postcompression
parameters were found within acceptable limits. From the obtained data it was concluded that,
the release rate was strongly influenced by the concentration of the polymers. The formulation
F1, F6 and F8 showed the maximum drug release up to 24 h. The mathematical treatment of in
vitro drug release data suggest that, selected formulations close to zero order and showed non-
Fickian (anomalous) release as all values of release exponent (n) are between 0.5-0.89.
