Matrix colon tablet formulation of Ciprofloxacin hydrochloride containing matrix carrier granules were prepared by wet granulation technology. The granular bed were evaluated for rheological properties indicated that, the granules were freely flowable and easily compressible. Granules were compressed in 10 station tablet punching machine and evaluated for post compressional characteristics of weight variation, thickness test, diameter test, hardness test, friability. The results showed that the pre formulation batches of tablets showed uniform and reproducible compressional characteristics. The drug content of tablet revealed that the drug is accurately and fairly distributed. The hardness (Kg/cm2) was found in the range of 4.5 ± 0.090 – 5.6 ± 0.201 Kg/cm2 with minimum friability. The colon targeted tablets were not disintegrated in 0.1N HCl. The in vitro drug release studies indicated that sterculia and almond gum could be used for development of colon matrix tablets of ciprofloxacin hydrochloride. The matrix tablet containing both gums was susceptible to bacterial degradation in presence of rat cecal content. The formulation containing more amount of sterculia gum is suitable as matrix carrier for colonic ciprofloxacin HCl matrix tablets.
