Present study aims to prepare and evaluate Gatifloxacin microspheres by ionotropic gelation method. Among all the formulations S12 was selected as optimized formulations for based on the physico chemical parameters and drug release studies. In the in vitro release study of formulation S12 showed 95.21% after 12 h in a controlled manner. In vitro drug release profile from optimized formulation was applied on various kinetic models. The best fit with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The innovator Abygate 400mg conventional tablet shows the drug release of 97.23 within 1 h. FT-IR and DSC analyses confirmed the absence of drug-polymer interaction. The results obtained from evaluation and performance study of different types of Gatifloxacin microspheres that system may be useful to achieve a controlled drug release profile suitable for peroral administration and may help to reduce the dose of drug, dosing frequency and improve patient compliance when compared with marketed product.
