Der Pharmacia Lettre
Abstract
Author(s): Vikrant Wankhade, Kiran Tapar, Shrikant Pande, Nishant Bobade
Self-nanoemulsifying drug delivery systems (SNEDDS) were developed with the objective to
overcome problems associated with the delivery of Gliclazide, a poorly bioavailable, anti-diabetic
having pH dependant solubility. Solubility of Gliclazide in oily phases and surfactants were
determined to identify components of SNEDDS. Various surfactants and co-surfactants were
screened for their ability to emulsify selected oily phases. Ternary phase diagrams were
constructed to identify area of nanoemulsification for the selected systems. The influence of
Gliclazide and pH of dilution medium on the phase behavior of selected system were assessed.
The globule size of optimized Gliclazide SNEDDS in various dissolution media was determined to
check the effect of pH on its behavior. The optimized Gliclazide SNEDDS needed surfactant
content less than 55% and yielded nanoemulsion of mean globule size 146 nm, which was not
affected by the pH of dilution medium. The optimized SNEDDS released the Gliclazide drug
completely within 20 min irrespective of the pH of dissolution medium.
