Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy, bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate immediate release tablets of divalproex sodium containing sodium starch glycolate (SSG) and croscarmellose as super disintegrating agents. The FTIR study revealed that there was no interaction between drug and polymer and combination can be safely prepared. The tablets were prepared by wet granulation technique as poor flow property exhibited by pure drug. Tablets were evaluated for hardness, thickness, weight variation, disintegration time, drug content and in vitro drug release. All the physical parameters were in acceptable limit of pharmacopeial specification. In vitro drug release studies were performed using USP type II apparatus (paddle method) in 900 ml of phosphate buffer pH 6.8 at 100 rpm. The optimized formulation (F6) was found to exhibit the highest in- vitrodrug release of 98.11percent at the end of 20 minutes. Further the drug release of immediate release tablets was compared with the drug release profile of conventional tablet which was prepared by using 5% micro crystalline cellulose (MCC) as disintegrating agent. The stability studies, shown the optimized tablets of immediate release formulation were stable at 400C / 75% RH for a period of 3 months.
