The present study was aimed to develop a novel fast dissolving drug delivery system for an antiasthamtic drug such as Salbutamol suphate. The fast dissolving films were prepared by solvent evaporation technique using different water-soluble polymers (hydroxy propyl methylcellulose, hydroxy propyl cellulose and Sodium Alginate) taken through sublingual route. In this study Tween 80 is used as a solubilizing agent and Aspartame is used as a sweetener. Concentration of water soluble polymers, Tween 80 and Aspartame were optimized during preliminary studies. The prepared films were evaluated for thickness, uniformity in drug content, folding endurance, disintegration time, swelling index, moisture loss, in-vitro drug release studies and drug-polymer compatibility studies. The results obtained showed no physicalchemical incompatibility between the drug and the polymers. The prepared films were clear, transparent and smooth surface. Film containing hydroxy propyl methylcellulose (2%w/w), Tween 80 (0.5%w/w) and Aspartame (0.5% w/w) showed optimum performance against all other prepared formulations.
