In the present study, Baclofen bi-layer tablets were formulated consisting of two layers such as fast releasing layer and sustaining layer. Fast releasing layer was prepared by using super disintigrant like sodium starch glycolate and sustained release layer was prepared by using synthetic polymer like hydroxy propyl methylcellulose K 15 (HPMC K15) by wet granulation method. The tablets were evaluated for physico-chemical properties such as hardness, friability, thickness, weight variation, drug content uniformity. The In vitro release studies were performed in 0.1 N HCl for first two hr and in 7.4-pH phosphate buffer up to 24 h. It was observed that bilayer matrix tablets having formulation code BH II which contained 65 % HPMC K15 were successfully sustained the release of drug up to 24 h. FT-IR studies revealed that there was no interaction between the drug and polymer used in the study.
