Predictive Microbiology is a branch of Food Microbiology that studies the microbial responses against several environmental factors that can be controlled, giving as a result responses that are quantified and summarized using mathematical equations. This study makes a review of the description and importance of some predictive models used as a tool in food conservation. Due to the fact that the application of mathematical models to the growth of microorganisms allows us to predict microbial behavior in storage conditions, its application may give to the establishment of the product´s shelf life a greater precision.