The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-bacterial drug, Ciprofloxacin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with Ciprofloxacin and targeted to the resistants produce strains of Staphylococcus aureus and Cryptococcus pneumonia. The antibacterial activity was carried out by cup and bore method to compare zone of inhibition with standard drug and plain PPI dendrimer.The study showed that the Ciprofloxacin loaded dendrimer has significant antibacterial activity than the plain PPI dendrimer, but standard drug was not shown zone of inhibition upon both microorganisms. In this study antibacterial activity of synthesized system are also relatively safer and hold potential to deliver some other drugs also.
