The aim of this study was to evaluate the hypoglycemic activity of the ethanolic extract of C.pulcherrima flowers in rat models. The ethanolic extract of C.pulcherrima was prepared using 90% ethanol by (1:4) ratio, at 35-400 C for 6hrs. The extract was distilled and concentrated. A single oral dose of 100, 200 and 300 mg/kg of the extract was evaluated for hypoglycemic activity in alloxan-induced (100 mg/kg) diabetic rats. The blood glucose level was determined at different time intervals i.e. acute and sub-acute. Then the histopathological studies were done for determination of the regeneration of β cells. Dosage of 200 and 300 mg/kg of the extract significantly decreased (p < 0.05) blood glucose levels in diabetic rats after 3 h, 1h respectively. There was no significant difference observed at 100 mg/kg. The histopathological study has shown better regeneration of β cells at 200mg/kg, 300mg/kg of extract. The obtained results have shown that the Caesalpinia pulcherrima flower ethanolic extract has anti-diabetic activity and detailed investigation is required by using the purified compound from the ethanolic extract of Caesalpinia pulcherrima.
