Increment in Lipoprotein(a) [LP(a)] serum concentration is an independent Coronary Artery Diseases (CAD) risk factor and clinical results support its roles in CAD. We assumed that aerobic and regular physical activity can reduce the amount of LP(a) and therefore play an important role to reduce the risk of CAD. But some previous studies have indicated that LP(a) levels can not affected by exercise training. In addition, some studies have demonstrated VO2max and LP(a) correlation but it's not consistent. The aim of this Cross-sectional study was to compare of correlation between physical activity and LP(a) in selected groups of active, sedentary and with CAD men. VO2max as a physical activity rating index estimated was based on non exercise prediction equations. Fasting serum concentration of LP(a) analysis with Immunoturbidimetric method. Pearson correlation equations between VO2max and LP(a) in groups are not significant. Therefore, LP(a) not been alter by physical activity.