The aim of this study was the comparison the effect of aerobic and resistance exercises on elderly men coagulation and fibrinolytic factors. This study subjects included 36 apparently healthy elderly men. The protocol used in this study was reviewed and approved by Sari University’s Institutional Review Board prior to participant recruitment and all participants provided written informed consent prior to beginning the study. As assessed by a medical history questionnaire, each participant was free of cardiovascular and neurological diseases, severe musculoskeletal injuries and low back pain. Firstly Subjects were tested between 8:00 and 10:00 h, according to the regular training. For measuring fibrinogen, pt and ptt the Coagulation method and for d-dimer measurement the Elisa was used. The platelet number analyzed via Diatron abacus machine. The Stago machine used for measuring the fibrinogen, pt and ptt. Results indicated that human hemostatic system affected by physical activity. The effect of aerobic training on Fibrinogen, prothrombin time, Partial thrombo-plastin time and Platelets number after 24 hour of latest training session remains permanent and these factors decreased due to aerobic training. The obtained results show the presence of active thrombin in about 50% of the vein thrombi. It is not found in the blood clot obtained in vitro. Thrombin in the vein thrombi evokes blood platelets aggregation and converts fibrinogen into fibrin.