Throughout the history the man has used several forms of therapy for relief of pain, among them; medicinal herbs have gained popularity because of its wide use and less side effect. Achyranthes aspera, for example is a commonly used folk medicine in India for various purpose. The plant root and leaf extract were prepared by using alcohol and distilled water in proportion (50:50). The extract of Achyranthes aspera was examined for centrally acting analgesic activity by using hot plate method, tail flick method and acetic acid induced writhing method for peripherally acting analgesic activity. The doses administered were 200 mg/kg and 400 mg/kg. The animal that administered a dose of 400mg/kg leaf extract has shown the maximum analgesic activity. The aspirin is taken as standard drug.
