The present investigation was carried out to compare the haematological and biochemical parameters in healthy and Monogenean infected Cyprinus carpio. The haematological analysis showed significant reduction (P<0.01) in RBC, haemoglobin, haematocrit (PCV) and lymphocyte in monogenean infected fishes, whereas total leucocyte count (TLC), neutrophils, eosinophils and monocytes significantly increased (P<0.01 and P<0.05) in infected test fish. The biochemical analysis showed significant reduction (P<0.01) in bilirubin content and blood glucose, SGOT and SGPT were significantly increased in the same test fish.