This study was conducted with the aim of assessing the acute effect of an intensive short term exercise session on some blood coagulation parameters and fibrinolysis between active and non-active male students. Method of this research was quasi-experimental. Statistical sample included 15 students in active group and 15 students in nonactive group age ranged 18 – 24 years who were randomly selected. The subjects were healthy without any disease. Training program involved one session of short term intensive exercise in which the subjects should pedal on ergo meter for 90 seconds with frequency of 90 pedals per minute. This research contained two stages of blood sampling, one before short term intensive exercise session and the other after exercise session. Blood sampling from active and non-active groups was done separately by physician in the physiology lab of university and at the end one way ANOVA and post hoc test LSD were used for determining within group and between group differences of active and non-active students respectively. The effect of one short term intensive exercise session on platelets number and blood fibrinogen concentration in active and non-active male students wasn’t significant (P ≥0.05) and this effect on prothrombin time and partial thromboplastin was significant (P ≤ 0.05).