Internet addiction”, “differences caused by overuse of the Internet” or “irrational and pathological use of the Internet” all are phrases used to describe one of the modern diseases caused by the Internet. Present research aims to comparatively study the mean Internet addiction among students of Zahedan and Kerman universities of medical sciences in 2014. The present research was a cross-sectional, descriptive-analytic study. The statistical sample included 220 students of Zahedan and Kerman universities of medical sciences in 2013 who were selected using the stratified random sampling method. A three-part questionnaire (demographics, Young’s Internet Addiction Test, and Spiritual Health Questionnaire) was used for collecting the require data and information. The results of this study showed that the mean age of students was 2.08 ± 21.19, in an age range of 18-35. In addition, 51.4%, 48.6%, 11.4%, and 88.6% of students were female, male, married, and single, respectively. In terms of educational grade, 75% of them were bachelor’s and 25% were PhD students. Based on total scores of Internet Addiction Test, 55.9% of students participated in this study were ordinary users and 35.9%, 5.9%, and 2.3% of them, respectively, were mild, moderate, and severe addicted users. One of the most important measures for the proper management of the Internet use is to set a specific time for the Internet use. In addition, understanding the attitudes and thoughts of individuals who spend much time surfing the net and are affected with some sort of Internet addiction helps us to develop and implement more disciplined and organized deterrence programs for Internet addiction.