Intravenous injection is the most common and important action in patients admitted to the hospitals. It may cause local or systemic complications or infections. One of the cases that can be effective in prevention of infection is to use appropriate skin disinfectant solution during injection. This study is a controlled, clinical, trial one in which two disinfectant solutionsof 2% Chlorhexidine and 70%alcohol were compared. The study population included patients admitted to the female orthopedic department of medical educational center of Alzahra Hospital affiliated to Isfahan University of Medical Sciences in Isfahan, Iran. The studied sample consisted of 100 venipuncture cases (50 cases with disinfectant solution of 2 %Chlorhexidine and 50 cases with %70%alcohol). SPSS software version 20.0 was use for data analysis .Results showed that out of the 100 cases of venipuncture, 59 cases of phlebitis were observed and the highest percentage of phlebitis was at the age of 50 years (70%). It has found that the use of 2% Chlorhexidine significantly reduced the cases and severity of venous phlebitis (P Value= 0.009). In the present study,2% Chlorhexidine solution was associated with lower phlebitis compared to 70%alcohol.
