Migraine is known as a mysterious risk factor for ischemic stroke. Different migraine mechanisms may affect developing of so-called migraine stroke.Homocysteineis an independent risk factor for ischemic stroke. It is believed that the homocysteine level of serum is increased in patients suffering from migraine; however, the information in this field is little and non-uniform. This study aims to evaluate the serum homocysteinelevel in patients suffering from migraine as compared to healthy people. In a case- control study, 65 patients suffering from migraine and 65 normal people who were in a same age and sex with patient group were studied for 12 months in Tabriz Shams hospital and other clinics. An immunoassay method was used to measure the homocysteine level of serum after 12 hours fasting. The results from two groups were compared. Sixty five patients suffering from migraine were studied that 38.5% of them were male and 61.5% of them were female with an average age of 27.69±9.50 (15-55) years and 65 normal people, with 41.5% male and 58.5% female with an average age of 27.42±8.25 (15-52) years (p>0.05).the mean level of serum in patient group is significantly higher than the control group (averagely 14.49±5.03 against 10.92±4.68 micromole in liter; p<0.001). The difference was still remaining after sex control. The percentage of the cases that were suffering from hyperhomocysteinemia was also significantly high in the same group (61.5% against 38.5%; p=0.01; odds ratio= 2.56). Serum homocysteine level in patients suffering from migraine is significantly high than in normal people.
