Comparative molecular field analysis (CoMFA) which is a three-dimensional quantitative structure activity relationship (3D-QSAR) technique was performed on 1,3,4-thiadiazole derivatives having anti-inflammatory activity. This study was performed using 28 compounds, in which the CoMFA model was developed using a training set of 25 compounds. Three compounds (selected at randomly served as a test set), which were not used in model generation, were used to validate the CoMFA model. CoMFA derived QSAR model shows a good conventional squared correlation coefficient r2 and cross validated correlation coefficient r2cv 0.980 and 0.617 respectively. In this analysis steric and electrostatic field contribute to the QSAR equation by 71.7% and 28.3% respectively, suggesting that variation in biological activity of the compounds is dominated by differences in steric interactions.
