New modified starches such as starch citrate and starch phosphate were prepared and evaluated as disintegrants in tablet formulations in comparison with sodium starch glycolate (SSG). Tablets of (i) Cetirizine (ii) Diclofenac sodium and (iii) Paracetamol were prepared by wet granulation method employing starch citrate and starch phosphate at 4% strength as disintegrant in the tablets. The formulated tablets were evaluated for various tableting properties, like hardness, thickness, friability, weight variation, disintegration time and dissolution rate. Comparative evaluation of the above-mentioned parameters established using sodium starch glycolate (SSG) as disintegrant at 4% strength in the tablets. Starch citrate and Starch phosphate exhibited good disintegrating properties like sodium starch glycolate.
