Der Pharmacia Lettre
Abstract
Author(s): Dhanashri K. Shete, Sharda S. Surve, Snehal B. Patil, Sarika B. Narade, Kiran S. Patil
and Yogesh V. Pore
This work was aimed to investigate the efficiency of various metal phosphates as a protomer in
the synthesis of multi-component condensation reaction. The multi-component reaction employed
in this work was a ternary condensation between urea/thiouea, an aldehyde and 1,3-dicorbonyl
compound. The metal phosphates utilized as a protomer in condensation reaction were mono
and dibasic phosphates of sodium and potassium metals (NaH2PO4, KH2PO4 and K2HPO4). The
efficiency of these phosphates were investigated in a common solvent; glacial acetic acid which
is a very cheap and cost-effective. Six different condensation products (4a-4f) were obtained by
using different aldehydes and 1,3-dicorbonyl compound to ensure reproducibility of the reaction.
The structures of all compounds were confirmed on the basis of spectral data (IR and 1HNMR).
Among the metal phosphates used, KH2PO4 demonstrated excellent efficiency as a protomer in
terms of excellent yields and purity as compared to other phosphates.
