The anti-nutrient contents of the pulp, seeds and rind of rambutanNepheliumlappaceumwere evaluated. The study was carried out on both fresh and dried samples. Results of the investigation revealled that the anti-nutritional components such as saponin, alkaloid, hydrocyanic acid, phenols, oxalate, tannins, phytates were detected in all the samples but at a varying tolerable concentrations. However, other anti-nutrient constituents were in small insignificant amount in all the parts of the fruits. Although there was a significant difference at (p< 0.05) in the antinutrient compounds in the different parts of the fruits, seeds and rind which are the parts always discarded on the basis of acclaim toxicity, their consumption can contribute immensely to recommended daily allowance and maintenance of good nutritional status and hence good health for both man and animals.