In vivo antioxidant properties of Chrysophyllum albidum leaves has been reported, but studies on C. albidum fruit juice are scarce. In the current study, we investigated the antioxidant potential of C. albidum fruit juice on ethylene glycol-induced oxidative stress on the erythrocytes. Experimental design involved twenty five (25) male Wistar rats randomly divided into five (5) study groups. Group 1 was administered with normal saline (Control), groups 2-4 were poisoned with ethylene glycol and treated with 0.2, 0.4 and 0.6 ml of C. albidum fruit juice respectively, and group 5 was poisoned with ethylene glycol, but not treated with C. albidum fruit juice. The results indicated that while there was a significant elevation (p < 0.05) in the level of lipid peroxidation product (MDA) in the group poisoned with ethylene glycol alone without treatment, lipid peroxidation levels were restored in the ethylene glycol poisoned rats that were treated with Chrysophyllum albidum fruit juice compared with the control. In addition, there were increases in the activities of glucose-6-phosphate dehydrogenase and catalase in all the groups except in the untreated group poisoned with ethylene glycol alone, where the enzymes activities were significantly (p < 0.05) reduced. We conclude therefore that C. albidum fruit juice possesses potent antioxidant property.
