Der Pharmacia Lettre
Abstract
Author(s): Mr. Sanjay K Singhai, Mr. Vikram Singh Chopra, Mrs. Mona Nagar, Ms. Namrata
Gautam, Mr. Piyush Trivedi
Recent advances in chronopharmacology and requirement of an appropriate technology to
deliver the drug at specific time and site led to the development of novel type of drug delivery
systems as ?¢????chronotropic drug delivery systems?¢???. Rationale behind designing these drug
delivery systems is to release the drug at desired time (pathophysiological need of disease),
which results into improved therapeutic efficacy and patient-compliance. These systems are
meant for treatment of those diseases that are caused due to circadian changes in body and when
zero order drug release is not desired. These drug delivery systems are designed to release the
drug within a short period of time, immediately after a predetermined lag time. Chronotropic
systems are promising drug delivery systems in asthma, peptic-ulcer ,cardiovascular diseases,
arthritis, attention-deficit syndrome in children and hypercholestremia e.t.c. Approaches like
capsular systems, systems with different type of barrier coatings, stimuli sensitive pulsatile
systems and externally regulated systems are summarized in this article. This article mainly
focuses on diseases requiring chronotropic systems, approaches to design them, recent
technologies for chronotherapy and currently available marketed formulations.
