Pollution is the major problem in the estuarine environment. The fishes in this environment have more gambles to get accumulated with the metals in their body. This study is to check the changes in the body of the fishes(Tilapia Mossambica), when their body gets accumulated with Mercuric chloride, Zinc sulphate and also with both the two metals. The phiso-chemical parameters in the estuarine water is checked and seemed it in normal level. The LC50 value for the meals was also found out. The blood glucose rose to +1555.529 in HgCl2 increase, +20.929 in ZnSo4 and 10.12 in both the metals concentration. Protein rise to +47.179 in HgCl2, +29.283 in ZnSo4 and 14.86 in both the metals. The Cholesterol also increased to +87.53, 8.758, and 1.97 in the increase of HgCl2, ZnSo4 and both respectively. Then the DNA raise in HgCl2 and both the metals concentration, the DNA reduces when the ZnSo4 concentration rises. The RNA count decrease in the HgCl2 concentration raise, In ZnSo4 raise in concentration it didn’t show any difference in the count and the RNA count increases when the concentration of both the metals raises.
