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Cerebral Palsy-A Curse: Etiology, Pathophysiology and Current Approach of Treatment | Abstract
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Central European Journal of Experimental Biology

Abstract

Cerebral Palsy-A Curse: Etiology, Pathophysiology and Current Approach of Treatment

Author(s): Bolay Bhattacharya*1, T. Mangilal1 and R. Nagakishore1,2

Cerebral palsy is Non-progressive, non-contagious motor conditions that cause physical disability in human development, chiefly in the various areas of body movement. Spastic cerebral palsy is by far the most common type of overall cerebral palsy, occurring in 80% of all cases. CT or MRI is warranted when the etiology of a patient's cerebral palsy has not been established – an MRI is preferred over CT due to diagnostic yield and safety. When abnormal, the neuroimaging study can suggest the timing of the initial damage. Botulinum toxin is used in focal treatment i.e. a limited number of muscles can be injected at the same time. The effect of the toxin is reversible and a reinjection is needed every 4–6 months. Selective dorsal rhizotomy (SDR) is a surgical procedure recommended only for cases of severe spasticity when all of the more conservative treatments – physical therapy, oral medications and intrathecal baclofen have failed to reduce spasticity or chronic pain. Transplanting stem cells into the brain could support and/or replace deteriorating brain tissue during the process of white matter damage in cerebral palsy.