Heart failure from a variety of causes is characterized primarily by the gradual loss of cardiomyocytes. Heart failure is a disorder where the heart is unable to sufficiently pump blood to meet the body's requirements for nutrients and oxygen. The heart muscle enlarges and weakens in heart failure with reduced ejection fraction, which reduces the heart's capacity to pump blood and causes fluid to accumulate in the body's tissues. Heart failure progresses over time in a way that is significantly influenced by inflammation. Therefore, there is a critical need for therapies that can help heart failure patients maintain or even increase the number of healthy cardiac myocytes
