The purpose of this study was to estimate the association between bovine lactoferrin (LTF) gene polymorphism and somatic cell score (SCS) of milk. According to general linear model, the relationship of bovine LTF gene with SCS of milk was studied. Association of LTF genotypes with SCS in milk was relatively high (pÃ?â?¹Ã?â??0.05). The results showed that DNA marker could be used in selection to improve susceptibility and mastitis resistance in Holstein dairy cows.