The present study deals with the effect of Nematode (Aspiculuris tetraptera) parasite on blood sugar of mice infected and treated with Aqueous and Methanol extract of Terminalia arjuna bark. The aim of present study was find out to effect of parasite on blood sugar level of host and effect of herbal drug on parasite. The mice carrying heavy infection showed decrease in the blood sugar but after drug (Aqueous and Methanol extract of Terminalia arjuna bark) treatment blood sugar was become on normal range due to killing of worm by drug. Methanol extract of Terminalia arjuna is more effective than aqueous extract of Terminalia arjuna. The decreased value of blood sugar in infected mice due to during nematode infection host consumes low quantity of food and nematode parasites consume the host blood glucose as food.