Liver is one of the most vulnerable organs for variety of insults such as chemical toxicants, viruses, drugs etc. Wide varieties of herbal formulations are in use to counter the hepatotoxicity due to such insults. However, there has always been a need for better agent, which can provide faster recovery. Drugs from herbal origin are the only treatment available for liver damage. Various herbs and their extracts are reported to possess hepatoprotective activity. Azadirachta indica commonly known as neem is claimed to be therapeutically useful to control leprosy, intestinal helminthiasis, blood morbidity, biliary affliction, skin infection, epistaxis, biliousness and anorexia.