In the present study, an attempt has been made to study the improved anti bacterial property of biocompatible polymer chitosan stabilized silver nanoparticles-azithromycin (CS-AgNp-AZ) and levofloxacin (LF) nano drug conjugate fabricated wound dressing against human pathogenic bacteria. Nano drug conjugate was prepared by chemical reduction of metal salt precursor with reducing agent and further stabilization with chitason by ionic gelation method. Synthesized nano drug conjugate characterized by Ultra Violet Visible Spectroscopy and Scanning Electron Microscopy.Synthesized nano drug conjugate was coated on the wound dressing by pad dry cure method and the fabricated dressing was further characterized by scanning electron microscopy which revealed complete dispersion of the particles on the fibre surface.The coated fabrics were examined in the range of basic physical– mechanical parameters such as the tensile strength, the bursting strength and air permeability.Distinct changes was not observed in the all the tested physical-mechanical properties of the nano drug conjugate coated dressing material.Anti bacterial activity revealed all the tested bacteria were highly susceptible to the both nano drug conjugate fabricated wound dressing.The present study would suggest the possible utilization of nano drug conjugate fabricated wound dressing against pyogenic bacteria and thus further development of biocompatible chitosan stabilized nano drug conjugate mediated anti microbial dressing.
