The present study was undertaken to explore the antihyperlipidemic effect of ethanolic extract of stems of Salvadora persica L. and its chloroform fraction in Triton induced hyperlipidemic rats. Flash chromatography was done for the most active fraction resulting in the isolation of Stigmast-5, 22-dien-3β-ol. Animals were administered with i.p. injection of Triton WR 1339 at dose of 400 mg/kg body weight. After 24 h. of Triton administration the ethanolic extract and its fraction were administered orally at doses of 200 and 400 mg/kg body weight in rats. The study dose dependently inhibited the total cholesterol, triglycerides, LDL level, and significantly increased HDL level. The chloroform fraction was found to be more effective in restoring lipid profile changes in rats treated with Triton probably due to the presence of Stigmast-5, 22-dien- 3β-ol .UV λmax was found to be 241 nm with a melting point of 168-170°C for the isolated component.
