In the past few decades, most Chinese researchers focused on terrestrial biological resources investigation. But during the last few years, marine organisms have received great attention. Due to the surviving environment, marine organisms are quite different from terrestrial ones. Especially for marine secondary metabolites, many of them have been found to be surprisingly effective as leading compounds. This review covers bioactive marine secondary metabolites isolation in China and total synthesis progress of several representative marine biomolecules by Chinese scientists in 2010-2015.