This study was designed to investigate the effect of Glossocalyxbrevipes (B) leaf and stem-bark extract on the kidney function of male Wistar albino rats. This investigation was based on the evaluation of risk of exposure using kidney function parameters: serum electrolytes (sodium, potassium, and chloride), serum albumin, serum urea and total protein. A total of 35 male wistar albino rats were weighed and randomly grouped into seven groups (five rats each). After the five days acclimatization, rats in Group 1, 2, 3 were orally administered aqueous extract of Glossocalyxbrevipes (B) leaf at 500mg/kg, 1000mg/kg and 2000mg/kg concentration respectively. Rats in Group 4, 5, 6 were orally fed the aqueous extract of Glossocalyxbrevipes (B) stem-bark at 500mg/kg, 1000mg/kg and 2000mg/kg respectively. Group 7 (control) was given 5ml/kg of distilled water.At the end of the twenty- one days experiment, blood samples were collected for biochemical assays. One-way analysis of variance (ANOVA) and least significant difference(LSD)test were used for data analysis. The results of the study shows that there was significant difference (p<0.05) in the serum levels of chloride (0.007mEq/L) (p <0.05), sodium (0.003mEq/L) (p<0.05) and albumin (0.348g/dl) (p<0.05) but there was no significant difference (p<0.05) in the serum levels of potassium(0.665mEq/L) (p<0.05), urea (0.874mmol/L) (p<0.05), total protein (0.503) (p<0.05). This study has therefore shown to some extent that aqueous stem-bark and leaf extract of Glossocalyxbrevipes(B) may not have significant effect on the kidney function of rats after a twenty-one day daily treatment. However, histological studies are needed to authenticate this claim.
