Buchanania lanzan Spreng. plant is well known for its medicinal and therapeutic values in Indian folk medicine. However, to be clinically useful, more scientific rationale are essential. Therefore, in the present study, we investigated the effects of ethanolic extract of Buchanania lanzan Spreng roots (EBL) for its antiulcer activity. To assess the antiulcer activity of varied concentrations of the EBL (200 and 400 mg/kg orally) was evaluated for ethanol induced ulcer in mice and pylorus ligation induced ulcer in rats. EBL showed a dose-dependent protection against gross damaging action of ethanol and Pylorus ligation on gastric mucosa of animals. The treatment with EBL shown significant protection of ulcer index in both the models as well as also inhibited the pylorus ligation-accumulated gastric secretion. Thus, our present study results clearly demonstrate that EBL is in possession of good preventive and therapeutic action on the gastric ulcers.
