The methanolic and aqueous extracts of Kleinia grandiflora (Asteraceae) was investigated for antipyretic activity in rats using brewer’s yeast-induced pyrexia model. Both the extract (200 and 400 mg/kg body weight p.o) produced a significant (p<0.05) inhibition of temperature elevation compared with the standard drug paracetamol (150mg/kg body weight). Peak antipyretic activity was observed by the methanolic extract at doses of 200 mg/kg b.w. These results indicate that Kleinia grandiflora leaves extracts possesses potent antipyretic effects and thus pharmacologically justifying its folkloric use in the management of fever.
