The present investigation, describes the phytochemical analysis, in vitro antioxidant and antidiabetic property of Muntingia calabura leaves extracts along with estimate the inorganic components of the leaves. The inorganic components present in the leaves were estimated by Narendhirakannan method. Total phenolic and flavonoid content in the extracts were estimated by Singleton and Zhishen method. Four complementary assays, total reductive power, total antioxidant activity, 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and metal chelating ability for ferrous ions were used to screen the antioxidant property of extracts and anti-hyperglycemic activity of extracts was screened in Streptozotocin-Nicotinamide induced type II diabetic in rat model. Ethanolic extract of leaves revealed the presence of high phenolic (33.33±0.13μg GAE/mg) and flavonoid (123.31±0.54μg CHE/mg) content. All extracts showed significant antioxidant activity in correlation to phytoconstituents of the extracts. Results showed that the ethanolic and aqueous extracts exhibited a higher antioxidant activity, while the chloroform and petroleum ether extracts was the least. Treatment of Streptozotocin-Nicotinamide induced type II diabetic rats with extracts caused significant reduction in fasting blood glucose level in a dose dependent manner. All the crude extracts showed dose dependent antioxidant and anti-hyperglycemic activity, capable of offering protection against free radical mediated damages
