The present study was to estimate the in-vitro antioxidant activity of whole plant of ethanolic extract of the Biophytum condolleanum wight and Clerodendrum viscosum vent .The dry powder was extracted with ethanol. Phytochemical test shows that extract contains higher level of total tannis and flavonoids. The extracts was screened for its potential antioxidant activities using DPPH scavenging activity, the in-vitro antioxidant assay showed Biophytum condolleanum wight posses potent antioxidant activity when compared with Clerodendrum viscosum vent. So Biophytum condolleanum wight could be useful for preparation of neutraceuticals as potent antioxidant to treat cancer and various human diseases and its complications.