In this present paper we have investigated the Antioxidant activity of Hydro-ethanol and Saponin fractions of Terminalia schimperiana root for its free radical scavenging activity by adopting ABTS and DPPH in vitro methods. The extracts were investigated for the antioxidant activity using 2,2- diphenyl, 1- picryl hydrazyl [DPPH] and 2, 2 azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) scavenging activity, reducing capacity and competition with DMSO. The result suggested that the polar Hydro-ethanol fraction was found to have potent DPPH antioxidant activity with IC50 value of 19.36 ± 0.436 μg/ml and ABTS scavenging activity with IC50 value of 0.9420 ± 0.011 μg/ml, while the Saponin fraction has moderate DPPH scavenging activity with IC50 of 59.33 ± 0.417 μg/ml and moderate ABTS scavenging activity with IC50 value of 2.273 ± 0.036 μg/ml (Rutin DPPH IC50 value= 14.5 ± 0.29 μg/ml, Rutin ABTS IC5O value= 0.2976 ± 0.012 μg/ml, Ascorbic acid ABTS IC50 value= 2.62 ± 0.20, Ascorbic acid DPPH IC50 value=9.51 ± 0.22).
