The partitionates of methanolic extract of the leaves of the plant Lasia spinosa at 200 mg/kg and 400 mg/kg were subjected for their antinociceptive activity using both acetic acid writhing method and radiant heat tail flicking method. The petroleum ether partitionate at 400 mg/kg induced significant decrease in the no. of writhes while the ethyl acetate partitionate at 400 mg/kg showed promising activity compared to standard diclofenac sodium. Similarly the petroleum ether partitionate elongates the reaction time significantly after administration of extract in radiant heat tail flicking method suggesting central antinociceptive activity.
