Many countries across the world are interested in natural healing products. They are less toxic products. The genus Myristica fragrans belongs to the family Myristicaceae. The various parts of the plant have been used in traditional medicine for the treatment of inflammation, vomiting, asthma, hypertension, diarrhea, polyarthritis and gout etc. In the present study, the pericarp of Myristica fragrans is extracted successfully with solvents methanol, ethanol and hexane using Soxhlet apparatus. Phytochemical screenings were performed as per the standard procedures. Alkaloids, Saponins, Phytosterols, tannins, flavonoids and proteins were identified as the major compounds. The antibacterial activities of extracts were studied for various microorganisms by broth dilution method using streptomycin as the standard drug. The methanolic and ethanolic extract of M.fragrans pericarp showed remarkable activity against Staphylococcus aurous and Salmonella typhi respectively. Based on this TLC and Column chromatography were performed on the more bioactive methanol extract. Further investigation on the structure elucidation of the bioactive compound was done using UV, IR, and GC-MS analysis. The results of the present study suggest that the extracts of M.fragrans pericarp contains compounds with antibacterial properties that can be used as antimicrobial agents for the therapy of infectious diseases caused by pathogens.
