The present study was carried out to evaluate the phytochemical and antibacterial activity of methanol, ethyl acetate and acetone extracts of Syzygium laetum bark. Antibacterial activity was analysed by agar well diffusion method against gram positive and gram negative bacteria. The phytochemical analysis carried out revealed the presence of alkaloids, coumarins, flavanoids, phenols, saponins, terpenoids, tannins and steroids in various solvent extracts. Methanolic extract of S. laetum showed good antibacterial activity against Bacillus subtilis, Pseudomonas aeruginosa and Klebsiella pneumoniaee. Acetone extract revealed similar zone of inhibition activity against Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus faecalis, Klebsiella pneumoniae and Bacillus subtilis where as ethyl acetate extract showed least zone of inhibition against tested all pathogens compared with other solvent extracts. From our results showed the presence of crucial phytoconstitients and good antibacterial activity and suggest that S. laetum can be used in the microbial tests.