A wide range of parts of the medicinal plant is used for extract as raw drugs and they possess varied medicinal properties. The different parts are used include root, stem, flower, fruit, twigs exudates and modified plant organs. One of the greatest accomplishments of modern medicine has been the development of antimicrobials for the treatment of infectious diseases. Microbial diseases remain a major challenge for modern science even today. Natural products are used as traditional medicines from ancient times. They are having a great importance in Ayurveda. One of the medicinal plant species is Ipomoea carnea belongs to convolvulaceae family and fistulosa sub-family. Antimicrobial activity was tested against n-hexane, ethyl acetate, acetone, ethanol and acetone fraction of acetone extract. The investigation is carried out against various gram positive and gram negative bacterial strains ( Escherichia coli ATCC – 11246; Staphylococcus aureus ATCC – 6538 P; Salmonella typhimurium ATCC – 23564; Pseudomonas aeruginosa ATCC – 27853; Proteus vulgaris ATCC – 13315; Bacillus cereus ATCC – 11778) . Disc diffusion method is employed for the detection of antimicrobial activity. Streptomycin was used as standard. The crude acetone extract (3) exhibits activity against Proteus vulgaris and Salmonella typhimurium, while the crude ethanol extract (4) ellucidates antimicrobial activity against Pseudomonous auroginosa.