To evaluate the anti-inflammatory, anti arthritis and analgesic activity of ethanolic extract of whole plant of Merremia emarginata in experimental animal models. Ethanolic extract of whole plant of (EME)(100, 200 and 400 mg/kg p.o) was studied for its anti inflammatory activity using carrageenan induced rat paw edema animal model, anti arthritis activity using complete freund’s adjuvant model and analgesic activity at the same dose level using Hot plate analgesia in mice. The Percentage inhibition with indomethacin and EME in the carrageenan induced paw edema at the dose level 400mg/kg were 82% and 74% at the end of 5hr. The results indicate that treatment of adjuvant induced arthritic rats with EME improves ESR, Hb value and also restores body weight. Significant (P<0.05) inhibitory effect was observed with EME on FCA induced paw edema throughout the study. In radiant tail flick method the extract at the dose 400mg/kg showed reaction time 5.9± 0.52 (P<0.05). the ethanolic e xtract possesses anti-inflammatory, anti arthritis and analgesic activity
