The aim of the present study is to evaluate the anti-inflammatory activity of Murraya koenigii leaves. The leaves and roots are bitter, acrid, cooling, anthelmintic, analgesic, it cures piles, allays heat of the body, reduces inflammation and itching. It is also useful in leucoderma and blood disorders. An infusion of the toasted leaves in used to stop vomiting. Crushed leaves are applied externally cures skin eruption and to relieves burn. For screening the activity The male wistar rats having weight (150-200g) were used. The petroleum Ether, chloroform and ethanol extracts were prepared by using soxhlet extraction method. The petroleum ether, chloroform and ethanol extracts of Murraya koenigii were screened at dose of (250mg/kg) for anti inflammatory activity by using acute carrageen induced paw oedema method and yeast induces hyperpyrexia method respectively. The ethanolic extract shows significant effects in anti-inflammatory activity. This study had rationalized the ethanomedicinal use of the plant for cut, injury & alignment of body temperature by treble people.