A Reaction of thiosemicarbazide with alkyle or fatty acids in presence of concentrated sulphuric acid led to the formation 2-amino-5-alkyle-1, 3, 4-thiadiazole which on further reaction with different p-substituted benzaldehydes yielded the Schiff’s base of N-(p-substituted benzylidene)-5-alkyle-1, 3, 4-thiadiazole-2-amines which is further reaction with thioglycollic acid in presence of small amount of zinc chloride in 1,4 dioxane as solvent gave title compounds. These compounds were characterized by spectral analysis and evaluated for their antifungal activities and their minimum inhibitory concentration (MIC) were determined.
