The concerned study reveals the experimental investigation of the biological activity of Euphorbia neriifolia (Family: Euphorbiaceae) used as a traditional antidiabetic and hypolipidemic agent in past and present culture. To study the effect of Euphorbia neriifolia in both normal and streptozotocin induced diabetic rats. The methanol stem extract of Euphorbia neriifolia at the dose of 200, 400 mg/kg body weight was administered orally once a day to the groups for 15 days. The fasting blood glucose, cholesterol, HDL cholesterol and serum triglyceride content were estimated in both normal and streptozotocin induced diabetic rats. The fasting blood glucose, cholesterol and serum triglyceride content were found to be significantly reduced (p< 0.05) in treated rats whereas the extract also showed the potent elevation in the level of serum HDL cholesterol. The study reveals that Euphorbia neriifolia has significant antidiabetic activity and a hypolipidemic activity in streptozotocin induced and normal fasting rats. The extract seems promising for the development of a phytomedicine for diabetes mellitus.
