The Antidiabetic activity of Anogeissus acuminata Roxburgh ex candolle (Family:Combretaceae) and Solanum pubescens Willd (Family:Solanaceae) were investigated in Alloxan induced diabetic albino rats. A comparison was made between both the plant extracts and a known antidiabetic drug Glibenclamide (5 mg/kg body weight). The dried leaves of Anogeissus acuminata and Solanum pubescens were subjected to extraction by continuous hot percolation using methanol as solvent and were subjected to standardization using pharmacognostical and phytochemical screening. Dose selection was made on the basis of acute oral toxicity study (300 mg/kg body weight) as per OECD and CPCSEA guidelines. Oral administration of extracts of Anogeissus acuminata (300mg/kg) and Solanum pubescens(300mg/kg) for 7 days resulted in a significant reduction in blood glucose levels. Alloxan induced diabetic rat model was used for the evaluation of antidiabetic activity. Activity is more for Solanum pubescens in comparision with Anogeissus acuminata. Solanum pubescens methanolic extract (SPME) and Anogeissus acuminata methanolic extract (AAME) showed significant (p<0.001) antidiabetic activity. These extracts also prevented body weight loss in diabetic rats. The drug has the potential to act as an antidiabetic drug.
